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Activation of mouse renin promoter by cAMP and c-Jun in a kidney-derived cell line

K Tamura¹, K Tanimoto, K Murakami

¹Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.

Biochimica Et Biophysica Acta

|March 20, 1993

Abstract:

We demonstrated that the mouse renin promoter from -365 to +16 can mediate the activation by cAMP and c-Jun in a kidney-cell dominant manner. Deletion analysis indicated that the region from -75 to -48 was responsible for the activation by cAMP. Furthermore, the core promoter region from -47 to +16 was sufficient to confer c-Jun inducibility.

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