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New instruments for high throughput receptor binding assays

N Roessler1, D Englert, K Neumann

  • 1Packard Instrument Company, Meriden, CT 06450.

Journal of Receptor Research
|January 1, 1993
PubMed
Summary
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New microplate scintillation counters enhance radioisotope assay efficiency for high-throughput receptor binding studies. These instruments significantly reduce counting time and improve sample handling in scientific research.

Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Instrumentation

Background:

  • High-throughput radioisotope assays are crucial for modern biological research.
  • Existing counting methods can be time-consuming and labor-intensive.

Purpose of the Study:

  • To introduce and evaluate the TopCount Microplate Scintillation Counter and Matrix 9600 Direct Beta Counter.
  • To assess their suitability for high-throughput radioisotope assays, specifically receptor binding assays.

Main Methods:

  • Description of the TopCount and Matrix 9600 instruments.
  • Investigation of assay protocols involving filtration (glass fiber mats, membrane filters).
  • Comparison of results with conventional liquid scintillation and gamma counting techniques.

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Main Results:

  • The microplate counters offer improved sample handling efficiency.
  • These instruments significantly shorten overall counting time for radioisotope assays.
  • Performance is comparable to standard counting techniques.

Conclusions:

  • The TopCount and Matrix 9600 are effective instruments for high-throughput radioisotope assays.
  • They provide a more efficient alternative for receptor binding studies.
  • These counters streamline laboratory workflows in scientific research.