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NADP-linked isozymes are the major forms of isocitrate dehydrogenase in mouse type-1-like astrocytes

B H Juurlink1

  • 1Department of Anatomy, University of Saskatchewan, Saskatoon, Canada.

Life Sciences
|January 1, 1993
PubMed

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...