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Nitrendipine modulates the sodium binding site of cardiac (Na,K)-ATPase
A Dzurba1, N Vrbjar, A Ziegelhoffer
1Institute for Heart Research, Slovak Academy of Sciences, Bratislava, CSFR.
Abstract:
The present study deals with the effect of calcium entry blocking agent, nitrendipine, on the rat heart sarcolemmal (Na,K)-ATPase. Nitrendipine (1 mumol/l) exerted a stimulatory effect on (Na,K)-ATPase activity. Kinetic analysis of enzyme activation by increasing concentrations of sodium in the presence of nitrendipine revealed a 67% increase in Vmax value and a decrease of the apparent Ka value to 33% of that in control. The observed influence on (Na,K)-ATPase may contribute indirectly to the calcium antagonistic effect of nitrendipine.
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