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Related Experiment Videos

Opioid antagonists and butorphanol dependence

S P Jaw1, B Hoskins, I K Ho

  • 1Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216.

Pharmacology, Biochemistry, and Behavior
|March 1, 1993
PubMed
Summary

Butorphanol dependence in rats was investigated using opioid receptor antagonists. Delta-opioid receptors, not mu-opioid receptors, appear to mediate butorphanol withdrawal symptoms, suggesting a key role for delta-receptors.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Addiction Research

Background:

  • Butorphanol interacts with mu-, delta-, and kappa-opioid receptors.
  • Morphine dependence is primarily mediated by mu- and possibly delta-opioid receptors.
  • Butorphanol exhibits higher affinity for mu- and delta-receptors compared to morphine.

Purpose of the Study:

  • To investigate the role of mu- and delta-opioid receptors in butorphanol dependence.
  • To precipitate withdrawal symptoms in butorphanol-dependent rats using specific antagonists.
  • To elucidate the receptor mechanisms underlying butorphanol-induced dependence.

Main Methods:

  • Utilized beta-funaltrexamine (beta-FNA), a mu-opioid antagonist, and naltrindole (NTI), a delta-opioid antagonist.
  • Administered varying concentrations of beta-FNA and NTI to butorphanol-dependent rats.

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  • Observed and quantified specific withdrawal behaviors following antagonist administration.

    • Main Results:

    • Beta-funaltrexamine (beta-FNA) did not induce significant withdrawal behaviors across tested concentrations (12-100 nM).
    • Naltrindole (NTI) precipitated various withdrawal signs, including teeth-chattering, wet shakes, tremors, yawning, ejaculation, and urination, at specific concentrations (24-100 nM).
    • Delta-opioid receptor blockade with NTI elicited pronounced withdrawal responses.

    Conclusions:

    • Delta-opioid receptors are implicated in mediating butorphanol dependence.
    • The role of mu-opioid receptors in butorphanol dependence requires further investigation.
    • These findings contribute to understanding the neurobiology of opioid dependence and the differential receptor actions of opioids.