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Epstein-Barr virus in angioimmunoblastic T-cell lymphomas
1Department of Histopathology, St Bartholomew's Hospital Medical College, London, UK.
Histopathology
|February 1, 1993
Summary
Epstein-Barr virus (EBV) was detected in most angioimmunoblastic lymphadenopathy (AIL)-like lymphomas, but its presence appears to be a consequence, not the cause, of this lymphoproliferative disorder.
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Angioimmunoblastic lymphadenopathy (AIL) is a progressive lymphoproliferative disorder.
- Epstein-Barr virus (EBV) has been implicated as a potential causative agent in AIL pathogenesis.
Purpose of the Study:
- To investigate the presence and role of Epstein-Barr virus (EBV) in angioimmunoblastic lymphadenopathy (AIL)-like lymphomas.
- To determine if EBV is a cause or consequence of AIL.
Main Methods:
- Studied 19 cases of AIL-like lymphomas.
- Utilized in situ hybridization to detect Epstein-Barr encoded RNAs (EBERs).
- Performed immunocytochemistry to detect EBV-encoded latent membrane protein (LMP).
Main Results:
- EBV was detected in 11 out of 19 AIL-like lymphoma cases.
- EBV was found in occasional cells in seven cases.
- EBV-encoded latent membrane protein expression was limited to cases with significant EBER detection and was less widespread than EBERs.
Conclusions:
- The presence of Epstein-Barr virus (EBV) in AIL-like lymphomas is likely a consequence of the disease process.
- EBV is unlikely to be the primary causative agent in the pathogenesis of AIL.
- Further research is needed to elucidate the exact role of EBV in AIL.