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[Opiates and opioids in the treatment of tumor-related pain]
1Abteilung für Onkologie und Hämatologie, Medizinische Klinik C, Kantonsspital St. Gallen.
Abstract:
Although opiates have been used by mankind for millenia and were undoubtedly during a long time among the most active drugs available, many unsettled questions have remained about their optimal use. In recent years new knowledge about active metabolites has been accumulated. An overview of the effects and side effects of morphine and various other opioids and their applications in the treatment of tumor pain is presented.
Insights
Opioids offer potent pain relief but optimal use remains debated. Recent research clarifies opioid metabolites, improving understanding of morphine and other opioid effects for effective tumor pain management.
Area of Science:
- Pharmacology
- Oncology
- Pain Management
Context:
- Opioids have a long history of use, yet optimal clinical application is still under investigation.
- Accumulated knowledge on opioid active metabolites is recent.
- Effective management of tumor pain remains a significant clinical challenge.
Purpose:
- To provide an overview of the effects and side effects of morphine and other opioids.
- To discuss the applications of opioids in treating tumor pain.
- To highlight recent advancements in understanding opioid metabolites.
Summary:
- This review examines the pharmacology of morphine and various opioids, including their active metabolites.
- It details the therapeutic applications and potential side effects of these agents in managing cancer-related pain.
- The discussion emphasizes the evolving understanding of opioid pharmacokinetics and pharmacodynamics.
Impact:
- Improved clinical decision-making for opioid selection and dosing in cancer pain.
- Enhanced patient outcomes through optimized pain management strategies.
- Foundation for further research into novel opioid-based analgesics and treatment protocols.