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Therapeutic advances in migraine
1Department of General Internal Medicine, Cleveland Clinic Foundation, OH 44195-5039.
Journal of Clinical Pharmacology
|March 1, 1993
Summary
Recent advances in understanding migraine pathophysiology and serotonin receptors have led to new treatments. New medications and dosage forms offer improved acute and prophylactic therapy for this debilitating neurological disorder.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a prevalent and disabling neurological disorder with poorly understood causes.
- Serotonin receptor research has significantly advanced migraine pathophysiology understanding.
Purpose of the Study:
- To review recent advancements in migraine pharmacotherapy.
- To highlight new and established treatments for acute and prophylactic migraine management.
Main Methods:
- Literature review of recent research on migraine pathophysiology and serotonin receptors.
- Analysis of newly available and updated medications for migraine treatment.
Main Results:
- New medications like sumatriptan are available for acute migraine attacks.
- Novel dosage forms of dihydroergotamine, NSAIDs, and phenothiazines are effective for acute treatment.
- Prophylactic options now include calcium-channel blockers, NSAIDs, fluoxetine, and valproate.
Conclusions:
- Recent therapeutic developments have improved management options for migraine sufferers.
- The outlook for individuals with disabling migraine has improved due to new pharmacotherapies.