Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral-type benzodiazepine receptors

A L Parola1, H I Yamamura, H E Laird

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85724.

Life Sciences
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.

European journal of pharmacology·2001
Same author

Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.

Molecular pharmacology·2001
Same author

Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE).

The Journal of pharmacology and experimental therapeutics·2001
Same author

Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.

Life sciences·2001
Same author

Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I.

The journal of peptide research : official journal of the American Peptide Society·2001
Same author

Biological properties of Phe(o)-opioid peptide analogues.

Life sciences·2001
Same journal

Corrigendum to "Adipose stem cells-derived microvesicles and chicken egg-derived exosomes attenuate cardiac ischemia/reperfusion injury through AKT/ERK/Nrf2/HO-1 axis to inhibit apoptosis and inflammation and restore autophagy" [Life Sci. 395 (2026) 124364].

Life sciences·2026
Same journal

MAGED1 stabilizes NEUROD1 to promote Per3 expression in the pineal gland.

Life sciences·2026
Same journal

TNF-centered network pharmacology and molecular modeling of selected Andrographis paniculata compounds in hypertension.

Life sciences·2026
Same journal

Retraction notice to "Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat" [Life Sci. 113 (2014) 22-30].

Life sciences·2026
Same journal

Soluble PD-1 drives renal fibrosis in CKD by disrupting immune homeostasis: Therapeutic mitigation via a targeted sPD-1 sequestration strategy.

Life sciences·2026
Same journal

METTL1 promotes hepatic steatosis by mediating m<sup>7</sup>G modification of ALOX15B mRNA.

Life sciences·2026
See all related articles

Peripheral-type benzodiazepine receptor (PBR) research reveals its nonneural roles and distinct molecular identity from central receptors. Studies highlight PBR

Area of Science:

  • Pharmacology
  • Biochemistry
  • Molecular Biology

Background:

  • Peripheral-type benzodiazepine receptor (PBR) initially identified as a high-affinity diazepam binding site in rat tissues.
  • PBR is ubiquitously distributed in mammalian tissues, concentrated in the outer mitochondrial membrane of secretory cells.
  • Brain PBR density can rival or surpass that of central-type benzodiazepine receptors.

Purpose of the Study:

  • To review recent advances in the pharmacology, biochemistry, and molecular biology of PBR.
  • To elucidate the nonneural effects of benzodiazepines mediated by PBR.
  • To clarify the relationship between PBR and central-type benzodiazepine receptors.

Main Methods:

  • Review of existing literature on PBR.
  • Analysis of high-affinity PK 11195 binding as a diagnostic marker for PBR.

Related Experiment Videos

  • Examination of cDNA cloning data for PBR components like isoquinoline binding protein (IBP).

    • Main Results:

    • High-affinity PK 11195 binding is a reliable diagnostic indicator for PBR.
    • Benzodiazepine affinity for PBR is species-dependent.
    • cDNA cloning of IBP reveals no sequence homology with GABAA receptor subunits, suggesting PBR is distinct from central receptors.

    Conclusions:

    • PBR plays significant nonneural roles and is molecularly distinct from central benzodiazepine receptors.
    • Further research into PBR's unique characteristics is warranted.
    • PBR represents a promising target for therapeutic interventions beyond the central nervous system.