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Ifosfamide-induced hyperpigmentation
M E Teresi1, D J Murry, A S Cornelius
1Division of Clinical/Hospital Pharmacy, University of Iowa College of Pharmacy, Iowa City 52242-1123.
Cancer
|May 1, 1993
Summary
Ifosfamide, a chemotherapy drug, can cause skin pigment changes, similar to cyclophosphamide. This case report highlights an uncommon adverse effect of ifosfamide in a child with Wilms tumor.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Cyclophosphamide, a chemotherapy agent, is known to cause nail banding and skin hyperpigmentation.
- Ifosfamide, a related chemotherapy drug, has not been previously reported to cause similar pigmentary changes.
Observation:
- A 5-year-old patient undergoing treatment for relapsed Wilms tumor experienced skin pigment alterations.
- The patient was treated with a combination of ifosfamide, MESNA, and etoposide.
Findings:
- This case presents the first reported instance of ifosfamide-induced skin pigment changes.
- A literature review confirmed no prior reports linking ifosfamide to pigmentary side effects.
Implications:
- Healthcare providers should be aware of this potential uncommon adverse effect of ifosfamide.
- Further research may explore the correlation between renal dysfunction and ifosfamide-induced pigmentary changes.