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Ditiocarb: decomposition in aqueous solution and effect of the volatile product on its pharmacological use
T Martens1, D Langevin-Bermond, M B Fleury
1Laboratoire de Chimie Analytique, URA C.N.R.S., Faculté de Pharmacie, Paris, France.
Abstract:
The kinetic profile for the decomposition of ditiocarb sodium salt in aqueous solution was achieved with UV-visible absorption spectrometry. The kinetic profile indicates that the decomposition reaction is hydrogen ion-catalyzed over the entire 4-10 pH range and enables the determination of the value of the acid-base equilibrium constant (Ka = 4.0.10(-4) at 5 degrees C). Decomposition of ditiocarb produces volatile carbon disulfide, exclusive of hydrogen sulfide, as shown with electrochemical methods. This feature is of interest from a toxicological point of view.
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