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[Extrabronchial small-cell carcinoma: apropos 6 cases]
L Cirera1, F Tresserra, G González-Pont
1Unidad de Oncología Médica, Hospital Mútua de Terrassa, Universidad de Barcelona.
Medicina Clinica
|April 10, 1993
Summary
Extrabronchial small cell carcinoma (ESCC) is a rare tumor. Immunohistochemical analysis revealed neuroendocrine markers in most cases, supporting a neuroendocrine origin.
Area of Science:
- Oncology
- Pathology
Background:
- Extrabronchial small cell carcinoma (ESCC) presents diagnostic and therapeutic challenges due to its rarity and uncertain origins.
- Understanding the immunohistochemical profile and clinical course of ESCC is crucial for effective management.
Observation:
- A 10-year review (1980-1989) of ESCC diagnoses was conducted.
- Immunohistochemical analysis using chromogranin, neurospecific enolase, and synaptophysin was performed on all ESCC cases.
- Clinical evolution data was collected for all patients diagnosed with ESCC.
Findings:
- ESCC accounted for 4.7% of all small cell carcinomas, with 6 cases identified.
- Primary ESCC sites included the parotid, urinary bladder, skin, maxillary sinus, and esophagus (2 cases).
- Five ESCC cases showed positivity for one or more neuroendocrine markers; two cases had associated squamous carcinoma.
Implications:
- Diagnosis of ESCC necessitates ruling out bronchial origin and ectopic hormone secretion syndromes.
- Chemotherapy regimens typically used for small cell lung carcinoma are recommended for ESCC treatment.