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Risk factors for multiple births

F Parazzini1, L Tozzi, L Bocciolone

  • 1Instituto di Richerche Farmacologiche Mario Negri, Milano, Italy.

Acta Obstetricia Et Gynecologica Scandinavica
|April 1, 1993
PubMed
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Family history significantly increases the risk of both dizygotic and monozygotic multiple births. Higher education levels were associated with a reduced risk of dizygotic pregnancies.

Area of Science:

  • Reproductive Epidemiology
  • Human Genetics

Background:

  • Multiple births, including dizygotic (fraternal) and monozygotic (identical) twins, can present unique obstetric considerations.
  • Understanding the risk factors for spontaneous multiple pregnancies is crucial for reproductive health management.

Purpose of the Study:

  • To investigate the epidemiological risk factors associated with spontaneous multiple pregnancies.
  • To differentiate between risk factors for dizygotic and monozygotic twins.

Main Methods:

  • A case-control study was conducted involving 103 women with multiple births and 308 controls with singleton deliveries.
  • Data collected included maternal education, family history of multiple births, and reproductive history.

Main Results:

Related Experiment Videos

  • A family history of multiple pregnancies was associated with increased relative risks (RR) for both dizygotic (RR=2.2) and monozygotic (RR=2.5) pregnancies.
  • Higher maternal education levels (7-11 and 12+ years) showed a reduced risk (RR=0.4) for multiple pregnancies, specifically for dizygotic twins.
  • No significant associations were found with factors like body mass index, contraceptive use, or abortion history.

Conclusions:

  • Family history is a significant risk factor for spontaneous multiple pregnancies.
  • Distinct epidemiological characteristics exist between dizygotic and monozygotic multiple births, particularly concerning maternal education and familial predisposition.