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High concentrations of glycine induce long-lasting changes in synaptic efficacy in rat hippocampal slices
K Shahi1, J C Marvizon, M Baudry
1Neuroscience Program, University of Southern California, Los Angeles 90089-2520.
Abstract:
Brief perfusion of adult rat hippocampal slices with high concentrations of glycine results in a slowly developing, long-lasting increase in synaptic responses in field CA1. Two observations indicated that the effect requires the activation of NMDA receptors by glycine. First, the glycine-induced potentiation is reduced by ketamine, an NMDA receptor channel blocker. Second, glycine potentiates the NMDA receptor-mediated epileptiform activity recorded in the presence of low magnesium concentration and picrotoxin. In slices prepared from rat pups (5-8 postnatal day), perfusion with glycine results in a slowly developing, long-lasting depression of EPSP amplitude. These results provide a new way of producing potentiation of synaptic efficacy and suggest new properties of NMDA receptors.