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[Cytokines and antagonists in septic shock]
1Département de pédiatrie, Hôpital des Enfants, Genève.
Schweizerische Medizinische Wochenschrift
|March 20, 1993
Summary
Natural inhibitors of tumor necrosis factor alpha (TNF alpha) and interleukin-1 (IL-1) show promise for treating septic shock. Understanding these cytokine regulatory mechanisms may lead to novel therapeutic strategies.
Area of Science:
- Immunology
- Pathophysiology
- Pharmacology
Context:
- Septic shock involves complex cytokine-mediated host responses.
- Tumor necrosis factor alpha (TNF alpha) and interleukin-1 (IL-1) are key inflammatory mediators.
- Natural inhibitory substances regulate these critical cytokines.
Purpose:
- To review the role of TNF alpha and IL-1 in septic shock pathogenesis.
- To explore natural inhibitory molecules targeting these cytokines.
- To discuss potential therapeutic strategies for septic shock.
Summary:
- TNF alpha drives neutrophil adherence, capillary leak, and coagulopathy in septic shock.
- Elevated circulating TNF alpha correlates with disease severity.
- Soluble TNF receptors (TNF-sR) and IL-1 receptor antagonist (IL-1 ra) neutralize cytokine effects.
- IL-1 ra has shown efficacy in experimental models and is in clinical trials.
Impact:
- Understanding cytokine regulation offers new therapeutic targets for septic shock.
- Inhibiting key cytokines like TNF alpha and IL-1 may improve patient outcomes.
- Development of antibody-based or natural inhibitor therapies for septic shock is advancing.