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Human herpesvirus-6

M T Caserta1, C B Hall

  • 1Department of Pediatrics, University of Rochester, Strong Memorial Hospital, New York 14642.

Annual Review of Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Human herpesvirus-6 (HHV-6) causes roseola infantum in children, with fever being a common symptom. Reactivation of this T-cell lymphotropic virus may link to immune system disorders.

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Area of Science:

  • Virology
  • Immunology
  • Pediatrics

Background:

  • Human herpesvirus-6 (HHV-6) is a T-cell lymphotropic virus.
  • It is a member of the herpes virus family with limited homology to human cytomegalovirus.
  • HHV-6 is the identified cause of exanthem subitum (roseola infantum).

Purpose of the Study:

  • To summarize the characteristics and implications of Human herpesvirus-6 (HHV-6) infection.
  • To highlight its role in childhood illness and potential links to immune dysfunction.

Main Methods:

  • Review of existing literature on HHV-6.
  • Analysis of epidemiological data regarding viral acquisition.
  • Postulation of reactivation mechanisms and associated conditions.

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Main Results:

  • HHV-6 is acquired early in childhood.
  • Fever is the most consistent symptom of primary HHV-6 infection.
  • Latent HHV-6 infection reactivation is a potential concern.

Conclusions:

  • HHV-6 is a significant viral agent in pediatric populations.
  • Understanding HHV-6 infection is crucial for diagnosing exanthem subitum.
  • Further research into HHV-6 reactivation is warranted for immune-related diseases.