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Human herpesvirus-6

M T Caserta1, C B Hall

  • 1Department of Pediatrics, University of Rochester, Strong Memorial Hospital, New York 14642.

Annual Review of Medicine
|January 1, 1993

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View abstract on PubMed

Summary
This summary is machine-generated.

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  • Biomedical And Clinical Sciences
  • Immunology
  • Immunology Not Elsewhere Classified
  • Human Herpesvirus-6

    • Human herpesvirus-6 (HHV-6) causes roseola infantum in children, with fever being a common symptom. Reactivation of this T-cell lymphotropic virus may link to immune system disorders.

    Area of Science:

    • Virology
    • Immunology
    • Pediatrics

    Background:

    • Human herpesvirus-6 (HHV-6) is a T-cell lymphotropic virus.
    • It is a member of the herpes virus family with limited homology to human cytomegalovirus.
    • HHV-6 is the identified cause of exanthem subitum (roseola infantum).

    Purpose of the Study:

    • To summarize the characteristics and implications of Human herpesvirus-6 (HHV-6) infection.
    • To highlight its role in childhood illness and potential links to immune dysfunction.

    Main Methods:

    • Review of existing literature on HHV-6.
    • Analysis of epidemiological data regarding viral acquisition.
    • Postulation of reactivation mechanisms and associated conditions.

    Main Results:

    • HHV-6 is acquired early in childhood.
    • Fever is the most consistent symptom of primary HHV-6 infection.
    • Latent HHV-6 infection reactivation is a potential concern.

    Conclusions:

    • HHV-6 is a significant viral agent in pediatric populations.
    • Understanding HHV-6 infection is crucial for diagnosing exanthem subitum.
    • Further research into HHV-6 reactivation is warranted for immune-related diseases.

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