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Related Experiment Videos

Hypertension in pregnancy

J Wacker1, S Lewicka, D Haack

  • 1Department of Obstetrics and Gynecology, University of Heidelberg, Germany.

The Journal of Steroid Biochemistry and Molecular Biology
|April 1, 1993
PubMed
Summary
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Pregnancy-induced hypertension (PIH) involves altered mineralocorticoid activity and reduced mineralocorticoid receptor (MR) counts. Urapidil shows promise for treating severe preeclampsia hypertension without adverse effects.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Obstetrics

Background:

  • Pregnancy-induced hypertension (PIH) is a significant cause of maternal and neonatal complications.
  • The pathophysiology of PIH involves mineralocorticoid imbalances and altered blood pressure patterns.
  • Continuous monitoring is crucial for managing preeclamptic mothers.

Purpose of the Study:

  • To investigate the role of mineralocorticoids in PIH pathophysiology.
  • To assess plasma aldosterone, 18-hydroxy-corticosterone (18-OH-B) levels, and mineralocorticoid receptor (MR) counts in PIH patients.
  • To evaluate continuous blood pressure monitoring and the efficacy of Urapidil in treating severe preeclampsia.

Main Methods:

  • Measured plasma aldosterone and 18-OH-B levels in 25 PIH patients and 25 healthy pregnant women.

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  • Quantified MR counts in mononuclear leukocytes from both groups.
  • Utilized a noninvasive, real-time blood pressure monitor (Finapres) and assessed Urapidil treatment in severe preeclampsia.

    • Main Results:

    • PIH patients exhibited significantly decreased MR counts.
    • Plasma aldosterone and 18-OH-B levels were lower in the PIH group.
    • Continuous blood pressure monitoring with Finapres showed good correlation with intraarterial measurements; Urapidil effectively treated hypertension without side effects.

    Conclusions:

    • The findings suggest a potential role for deoxycorticosterone or an unknown mineralocorticoid in PIH, rather than simple receptor down-regulation.
    • Continuous blood pressure monitoring is a reliable method for preeclampsia management.
    • Urapidil is a safe and effective option for treating hypertension in severe preeclampsia, warranting further investigation for prepartal use.