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EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat
S Sato1, T Tominaga, T Ohnishi
1Philadelphia Biomedical Research Institute, King of Prussia, PA 19406.
Biochimica Et Biophysica Acta
|April 30, 1993
Abstract:
The formation of nitric oxide (NO) radicals was demonstrated by electron paramagnetic resonance spectroscopy in the rat during varying degrees of brain ischemia. Diethyldithiocarbamate and Fe-citrate were used as in vivo spin-trapping reagents. The signal of NO spin adducts increased in accordance with the degree of ischemic insults. The formation of NO radicals was inhibited by NG-nitro-L-arginine methyl ester.