Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cellular retinoid-binding proteins]

M Okuno1, S Numaguchi, H Moriwaki

  • 1First Department of Internal Medicine, Gifu University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative routine evaluation of bilateral adrenal glands by endoscopic ultrasound and fine-needle aspiration in patients with potentially resectable lung cancer.

Endoscopy·2013
Same author

Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal nodal staging of lung cancer.

Endoscopy·2011
Same author

Carbon dioxide insufflation vs. conventional saline irrigation for peroral video cholangioscopy.

Endoscopy·2011
Same author

Percutaneous transluminal angioplasty for intracranial arteriosclerotic lesions.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same author

Intra-arterial Thrombolytic Therapy for Acute Vertebrobasilar Artery Occlusion.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same author

Percutaneous Transluminal Angioplasty for Bilateral ICA Occlusive Lesions.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Cellular retinoid-binding proteins (CRBP, CRABP) manage vitamin A transport, metabolism, and signaling. Recent research clarifies their roles in cellular uptake, intracellular transport, and biosynthesis, impacting retinoid homeostasis and development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Context:

  • Retinoids, vitamin A derivatives, are crucial for vision, gene expression, and cellular differentiation.
  • Cellular retinoid-binding proteins (CRBPs) and receptors (RARs) play vital roles in retinoid metabolism and function.
  • Understanding these proteins is key to deciphering retinoid signaling pathways.

Purpose:

  • To review the diverse functions of cellular retinoid-binding proteins, including CRBP, CRABP, and CRALBP.
  • To highlight recent advancements in understanding retinoid cellular uptake, transport, biosynthesis, and metabolism.
  • To elucidate the specific roles of different CRBP and CRABP isoforms in various physiological and developmental processes.

Summary:

  • Cellular retinol-binding protein (CRBP) facilitates retinol uptake, transport, and conversion to retinoic acid or retinyl esters.

Related Experiment Videos

  • Cellular retinoic acid-binding protein (CRABP) modulates retinoic acid levels by sequestering or catabolizing the molecule, influencing gene expression.
  • CRABP (II) is implicated in regulating retinoic acid's morphogenetic role during fetal development, while CRBP (II) aids intestinal absorption.

    • Impact:

    • Provides a comprehensive overview of retinoid-binding protein functions, aiding researchers in the field.
    • Identifies knowledge gaps, particularly regarding CRBP (III) function, stimulating further investigation.
    • Enhances understanding of retinoid's role in development and disease, potentially informing therapeutic strategies.