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Related Experiment Videos

Anaplastic large cell lymphoma with histiocytic phenotypes

S Sakurai1, T Nakajima, T Oyama

  • 1Second Department of Pathology, Gunma University School of Medicine, Maebashi, Japan.

Acta Pathologica Japonica
|March 1, 1993
PubMed
Summary

A rare lymphoid neoplasm presented aggressively in a 38-year-old man. The tumor exhibited characteristics of both anaplastic large cell lymphoma and histiocytic cells, posing diagnostic challenges.

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Area of Science:

  • Oncology
  • Hematopathology
  • Immunohistochemistry

Background:

  • Sudden death in young adults can be caused by aggressive neoplasms.
  • Lymphoid neoplasms encompass a diverse group of cancers affecting lymphocytes.

Observation:

  • A 38-year-old male experienced rapid deterioration and succumbed to a widespread lymphoid neoplasm.
  • Histological examination revealed pleomorphic large cells with significant phagocytic activity.
  • Histochemical and immunohistochemical analyses indicated co-expression of anaplastic large cell lymphoma and histiocytic cell markers.

Findings:

  • Immunogenotyping did not confirm a lymphoid origin for the tumor cells.
  • The tumor displayed a unique phenotype, merging features of anaplastic large cell lymphoma and histiocytic cells.

Related Experiment Videos

  • This challenging case suggests a potential classification as anaplastic large cell lymphoma with histiocytic phenotypes.

    • Implications:

    • This case highlights the importance of comprehensive diagnostic approaches in challenging hematolymphoid neoplasms.
    • Understanding mixed phenotypes is crucial for accurate diagnosis and treatment of rare cancers.
    • Further research into neoplasms with overlapping lymphoid and histiocytic features is warranted.