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Oncogenic osteomalacia: imaging studies

E Leicht1, B Kramann, G Seitz

  • 1Medizinische Klinik und Poliklinik, Universität des Saarlandes, Homburg/Saar.

Bildgebung = Imaging
|March 1, 1993
PubMed
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Tumor-induced hypophosphatemic osteomalacia (OM) resolved after surgical excision of a synovial sarcoma. Imaging revealed tumor vascularity and calcification, with resolution of osteomalacia post-surgery.

Area of Science:

  • Oncology
  • Radiology
  • Endocrinology

Background:

  • Hypophosphatemic osteomalacia (OM) is a rare metabolic bone disease.
  • Tumor-induced OM is often associated with mesenchymal tumors.
  • Early diagnosis and treatment are crucial for managing OM.

Observation:

  • A 34-year-old patient presented with tumor-induced hypophosphatemic osteomalacia.
  • Initial imaging showed features of OM and periosteal new bone formation.
  • Conservative treatment improved bone density but did not resolve Looser's zones.

Findings:

  • A low-grade synovial sarcoma in the first left metatarsal space was identified.
  • The tumor exhibited hypervascular and partially calcified structures.
  • Surgical excision of the tumor led to complete resolution of osteomalacia signs.

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Implications:

  • This case highlights the importance of considering tumor-induced OM in patients with unexplained bone disease.
  • Advanced imaging techniques like NMR and angiography are valuable for characterizing tumor vascularity.
  • Surgical tumor removal is an effective treatment for tumor-induced OM, leading to full recovery.