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Spontaneous renal neoplasms in rats
M Chandra1, M G Riley, D E Johnson
1Wilbur G. Malcolm Toxicology Laboratories, American Cyanamid Company, Pearl River, NY 10965.
Journal of Applied Toxicology : JAT
|March 1, 1993
Summary
Spontaneous renal tumors are rare in rats. This study details the types and incidence of kidney tumors in Sprague-Dawley and Fischer-344 rats across multiple carcinogenicity studies.
Area of Science:
- Toxicologic Pathology
- Oncology
- Rodent Models
Background:
- Spontaneous renal neoplasms are infrequently reported in laboratory rats.
- Understanding baseline tumor incidence is crucial for interpreting carcinogenicity study results.
Purpose of the Study:
- To document the incidence and histopathological characteristics of spontaneous renal tumors in control Sprague-Dawley and Fischer-344 rats.
- To provide reference data for long-term rodent carcinogenicity studies.
Main Methods:
- Retrospective analysis of renal tumors from control Sprague-Dawley and Fischer-344 rats across 17 and 10 carcinogenicity studies, respectively.
- Histopathological examination and classification of observed renal neoplasms.
Main Results:
- Renal cell adenoma, lipoma/liposarcoma, and transitional cell carcinoma were observed in both rat strains, with higher incidence in Fischer-344 rats.
- Transitional cell papilloma and nephroblastomas were noted in Sprague-Dawley rats, with some cases showing metastasis.
- Tumor incidence was generally higher in male rats compared to females across both strains.
Conclusions:
- Spontaneous renal tumors, though uncommon, occur in Sprague-Dawley and Fischer-344 rats.
- The data provide valuable histopathological context for assessing chemically induced renal tumors in these models.
- Sex-based differences in spontaneous renal tumor incidence warrant consideration in study design and interpretation.