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[Nuclear state splitting: a working model for the mechanochemical coupling of differentiation "waves" with the
1University of Manitoba, Winnipeg, Canada.
Ontogenez
|March 1, 1993
Abstract:
The cell state splitter (CSS) model for differentiation, supported by recent evidence, requires that an intracellular mechanical events result in a commitment signal to the nucleus that determines which of two readied gene cascades is to be activated, via their master genes. We show how a link between the mechanochemistry of cell state splitting and the molecular genetics of "nuclear state splitting" might be forged out of well known molecular components of cells.