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Alterations in human lung adrenergic receptors in cancer
T Y Kondratenko1, I V Zacharova, N V Kuzina
1Research Center of Molecular Diagnostics and Therapy, Moscow, Russia.
Biochemistry and Molecular Biology International
|January 1, 1993
Abstract:
Data on human lung alpha 1- and beta-adrenoceptors and the alpha 1/beta adrenergic ratio in cancer and chronic inflammatory processes are reported. The number of alpha 1-adrenergic sites markedly increased in lung cancer parenchyma, giving a ratio of alpha 1/beta binding sites of 12/1 in cancer but almost 1:1 in control specimens. The alpha 1/beta adrenergic ratio obtained both for mild and severe chronic pneumonia and tuberculosis lung parenchyma was similar to that demonstrated for normal tissue. The above findings suggest the cancer-induced enhancement in parenchymal alpha 1-adrenergic activity.