Genetic implications for long-term survivors of childhood cancer

The author reviews current findings regarding inherited cancer predisposition and childhood cancer and proposes development of genetic services for long-term survivors of childhood cancer. Overall, it is suggested that relatively rare germline mutations in the tumor suppressor genes, Rb, p53, and WT1, may have important implications for long-term survivors relevant to familial cancer, second malignant neoplasms, and developmental disorders. Although continued research clearly is needed, planning for genetic services for long-term survivors should begin now.