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Sex differences in colonic function: a randomised trial

J W Lampe1, S B Fredstrom, J L Slavin

  • 1Department of Food Science and Nutrition, University of Minnesota, St Paul.

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|April 1, 1993
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Summary
This summary is machine-generated.

Men and women exhibit distinct gut responses to identical dietary fiber intakes, impacting transit time, stool weight, and bile acid excretion. These sex differences in bowel function may influence colonic disease development.

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Area of Science:

  • Gastroenterology
  • Human Nutrition
  • Dietary Fiber Research

Background:

  • Sex differences in gastrointestinal disorder prevalence suggest underlying biological variations.
  • Understanding these differences is crucial for targeted health interventions and disease prevention.

Purpose of the Study:

  • To investigate sex-specific gastrointestinal responses to controlled dietary fiber consumption.
  • To compare bowel function and metabolic markers between men and women on identical fiber diets.

Main Methods:

  • A randomized controlled trial involving 16 women and 18 men.
  • Participants consumed liquid formula diets with 0g, 10g, and 30g of wheat bran and vegetable fiber over 23-day periods.
  • Measurements included mean transit time, stool weight, fecal pH, moisture, neutral detergent fiber (NDF) excretion/digestibility, and secondary bile acid concentrations.

Main Results:

  • Men exhibited faster mean transit times and greater stool weights compared to women (p < 0.05).
  • Men had higher neutral detergent fiber (NDF) excretion, while women showed a trend towards greater NDF digestibility (p < 0.06).
  • Secondary bile acid concentrations (lithocholic and deoxycholic acid) were significantly higher in men (p < 0.05).

Conclusions:

  • Significant gender differences exist in bowel function and bile acid metabolism when consuming equivalent dietary fiber.
  • These findings highlight the importance of considering sex in the context of colonic disease etiology and dietary interventions.