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Recurrent meningococcal infections in a patient with congenital C5 deficiency
A Bols1, J Janssens, W Peetermans
1Department of General Internal Medicine, University Hospitals, K. U. Leuven, Belgium.
Abstract:
A congenital C5 deficiency was the cause of recurrent meningococcal disease in a 27-year-old man. The lack of serum bactericidal activity accounts for the higher incidence and the different course of Neisseria infections in patients with a deficiency of the late complement components. Early antibiotic treatment and vaccination with a capsular polysaccharide meningococcal vaccine (A,C,Y,W-135) should be considered.
Insights
A rare C5 complement deficiency caused recurrent meningococcal disease in a 27-year-old man. Early antibiotics and vaccination are recommended for individuals with this rare immune deficiency.
Area of Science:
- Immunology
- Infectious Diseases
- Genetics
Background:
- Recurrent Neisseria infections can indicate underlying immune system dysfunction.
- Deficiencies in late complement components impair the body's ability to fight certain bacterial infections.
Observation:
- A 27-year-old male presented with recurrent meningococcal disease.
- Congenital deficiency of the C5 complement component was identified as the cause.
Findings:
- C5 deficiency leads to a lack of serum bactericidal activity against Neisseria meningitidis.
- This deficiency explains the increased incidence and altered disease course of Neisseria infections.
Implications:
- Early antibiotic intervention is crucial for patients with C5 deficiency experiencing meningococcal disease.
- Vaccination with capsular polysaccharide meningococcal vaccines (serogroups A, C, Y, W-135) is recommended for prevention.