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Related Experiment Videos

Primary hepatic vipoma

A Ayub1, M Zafar, A Abdulkareem

  • 1Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

The American Journal of Gastroenterology
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

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A rare case of primary hepatic vipoma syndrome is presented, where a liver tumor caused severe diarrhea and weakness. Surgical removal of the tumor resolved all symptoms, highlighting a novel treatment approach for this condition.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Oncology

Background:

  • Vasoactive intestinal polypeptide (VIP) secreting tumors, known as vipomas, are rare neuroendocrine neoplasms.
  • While commonly originating in the pancreas or gastrointestinal tract, primary hepatic vipomas are exceedingly uncommon.

Observation:

  • A 35-year-old male presented with a three-year history of voluminous watery diarrhea and episodes of severe generalized weakness.
  • Investigations revealed a solitary liver mass and elevated serum levels of vasoactive intestinal polypeptide.
  • Extensive work-up excluded other primary tumor sites.

Findings:

  • Surgical resection of the solitary liver mass was performed.
  • Post-operatively, the patient's symptoms resolved completely.

Related Experiment Videos

  • Serum VIP levels decreased significantly following tumor removal.

    • Implications:

    • This case suggests primary hepatic vipoma syndrome is a potential, albeit rare, cause of secretory diarrhea.
    • Successful surgical management underscores the importance of considering hepatic vipomas in unexplained VIP excess.
    • This report expands the known spectrum of vipoma origins and management strategies.