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Effect of okadaic acid on leukocyte movement
1Department of Bacteriology, Osaka City University Medical School, Japan.
Biochemistry and Molecular Biology International
|April 1, 1993
Abstract:
The effect of Okadaic acid (OA), a potent inhibitor of intracellular phosphatases, on neutrophil movement was studied. 1) Random movement was suppressed by OA at a concentration of 200 ng/ml. 2) Chemotaxis was suppressed by OA at concentrations between 50 and 100 ng/ml and completely suppressed at concentrations above 200 ng/ml. 3) Phagocytosis (latex particles) was suppressed by OA at concentrations more than 100 ng/ml.