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Related Experiment Videos

Large airway constriction in allergic rhinitis

R D Fairshter, J T Chiu, A F Wilson

    The Journal of Allergy and Clinical Immunology
    |March 1, 1977
    PubMed
    Summary

    Asymptomatic allergic rhinitis patients exhibit large airway narrowing due to bronchoconstriction, not small airway obstruction. Pulmonary function tests reveal abnormal airways resistance (RAW) and specific conductance (SGAW) that normalize after bronchodilator treatment.

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    Area of Science:

    • Pulmonary Medicine
    • Allergology
    • Respiratory Physiology

    Background:

    • Allergic rhinitis is a common condition that can affect respiratory health.
    • The impact of allergic rhinitis on lung function, particularly in asymptomatic individuals, requires further investigation.
    • Understanding the specific sites of airway involvement in allergic rhinitis is crucial for targeted treatment.

    Purpose of the Study:

    • To investigate pulmonary function in asymptomatic patients with allergic rhinitis.
    • To determine if allergic rhinitis is associated with small airways obstruction or large airway narrowing.
    • To assess the effect of bronchodilators on lung function in these patients.

    Main Methods:

    • Extensive pulmonary function tests were conducted on 16 asymptomatic allergic rhinitis patients and 31 healthy controls.

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  • Tests included measurements of lung volumes, flow rates, airways closure, ventilation distribution, and diffusing capacity.
  • Airways resistance (RAW) and specific conductance (SGAW) were specifically analyzed, with and without inhaled bronchodilators.

    • Main Results:

    • No significant differences were observed in lung volumes, flow rates, or diffusing capacity between groups.
    • Patients with allergic rhinitis showed significantly higher RAW and lower SGAW compared to controls.
    • Isoproterenol administration normalized RAW and SGAW in rhinitis patients, indicating reversible bronchoconstriction.
    • Only 3 patients had abnormal RAW and SGAW, which improved with treatment.

    Conclusions:

    • Asymptomatic allergic rhinitis is associated with large airway narrowing (trachea/major bronchi) due to bronchoconstriction.
    • There is no evidence of diffuse or small airways obstruction in these patients.
    • The observed airway narrowing is reversible with bronchodilator therapy.