Mu and kappa opioid systems modulate responses to cutaneous perioral stimulation in the fetal rat

The prenatal ontogeny of functional mu and kappa opioid systems was investigated in a series of four experiments conducted with rat fetuses on the last day of gestation (E21). Fetal motor activity and responsiveness to cutaneous stimulation were measured following administration of various opioid agonists, including morphine, DAMGO, U69,593, and U50,488. The effectiveness of selective mu (CTOP) and kappa (nor-binaltorphimine) antagonists to block the effects of opioid agonists, and the effects of combined administration of DAMGO and U69,593, also were assessed. These experiments provide evidence that both mu and kappa opioid systems are functional and are capable of modulating fetal behavior during the late prenatal period. The data also suggest that different subclasses of kappa receptors may mediate different aspects of fetal behavior. These findings suggest a role for endogenous opioids in regulating important aspects of perinatal behavior, including the development of suckling, maternal-infant interaction and early learning at the nipple.