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Behavioural mechanisms in AIDS patients under stress
East African Medical Journal
|January 1, 1993
Abstract:
Clinical observation at the Kenyatta National Hospital showed unusually rapid deterioration of patients testing seropositive to HIV infection and being moved to a side room for nursing. This pilot study tested the hypothesis that deterioration was at least partly, mediated by B-endorphins and other endogeneous opioids. The study design was a prospective and comparative study looking at 6 HIV seropositive and 10 control (HIV seronegative) patients matched for sex, age, and clinical status at time of study. The laboratory measures compaired were baseline, and daily serum B-endorphin and ACTH. A significant variation is noted between the two groups. The significance of this study is discussed.
Keywords:
Acquired Immunodeficiency SyndromeAdrenal Cortex HormonesAfricaAfrica South Of The SaharaBehaviorBiologyCase Control StudiesControl GroupsData AnalysisDeveloping CountriesDiseasesEastern AfricaEndocrine EffectsEndocrine SystemEnglish Speaking AfricaExaminations And DiagnosesHiv InfectionsHormonesImmunityKenyaLaboratory Examinations And DiagnosesLaboratory ProceduresMatched GroupsMultivariate AnalysisPhysiologyPsychological FactorsResearch MethodologyStressStudiesViral Diseases