Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How Y chromosomes become genetically inert

M Steinemann1, S Steinemann, F Lottspeich

  • 1Institut für Genetik und Mikrobiologie, Universität München, Federal Republic of Germany.

Proceedings of the National Academy of Sciences of the United States of America
|June 15, 1993
PubMed
Summary

Larval cuticle protein genes (Lcp1-4) in Drosophila miranda are silenced on the Y chromosome due to transposable elements. This inactivation is a key step in Y chromosome degeneration during evolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A needs assessment of education research topics among surgical educators in the United States.

American journal of surgery·2016
Same author

Improved detection of anterior fibromuscular stroma and transition zone prostate cancer using biparametric and multiparametric MRI with MRI-targeted biopsy and MRI-US fusion guidance.

Prostate cancer and prostatic diseases·2015
Same author

Sequence homologies between glyoxysomal and mitochondrial malate dehydrogenase.

Planta·2013
Same author

Characterization of proteins associated with self-incompatibility in Solanum tuberosum.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Sequence analysis of proteolytic fragments of 124-kilodalton phytochrome from etiolatedAvena sativa L.: Conclusions on the conformation of the native protein.

Planta·2013
Same author

EuPA achieves visibility - an activity report on the first three years.

Journal of proteomics·2008

Area of Science:

  • Evolutionary genetics
  • Molecular biology
  • Drosophila genetics

Background:

  • Larval cuticle protein (Lcp) genes are typically autosomal in Drosophila.
  • In Drosophila miranda, Lcp genes are found on the X2 and neo-Y chromosomes, indicating a significant evolutionary shift.
  • The Y chromosome in D. miranda is known to be undergoing degeneration.

Purpose of the Study:

  • To investigate the mechanistic basis for the inactivation of Lcp genes on the neo-Y chromosome in Drosophila miranda.
  • To understand the role of transposable elements in Y chromosome degeneration.
  • To elucidate the evolutionary trajectory of sex chromosomes in Drosophila.

Main Methods:

  • Comparative genomics analysis of Lcp gene locations across Drosophila species.

Related Experiment Videos

  • Gene expression analysis of Lcp1-4 loci on the X2 and neo-Y chromosomes.
  • Investigating the genomic environment of Lcp loci on the neo-Y chromosome, focusing on transposable element content.

    • Main Results:

    • The Lcp1-4 genes are located on both X2 and neo-Y chromosomes in D. miranda.
    • All four Lcp loci are expressed on the X2 chromosome.
    • On the neo-Y chromosome, Lcp3 shows reduced activity, while Lcp1, Lcp2, and Lcp4 are completely silenced.
    • The Y-linked Lcp loci are embedded within dense clusters of transposable elements.

    Conclusions:

    • Transposable elements play a critical role in silencing Y-linked genes, such as Lcp1 and Lcp3, in D. miranda.
    • Gene silencing mediated by transposable element accumulation is a likely initial step in Y chromosome degeneration.
    • These findings provide mechanistic insights into the evolutionary process of Y chromosome loss in Drosophila.