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Related Experiment Videos

Platelet activation in mental stress

O Naesh1, C Haedersdal, I Hindberg

  • 1Department of Anesthesiology and Intensive Care, Sahlgrenska Sjukhuset, Gothenburg, Sweden.

Clinical Physiology (Oxford, England)
|May 1, 1993
PubMed
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Mental stress activates platelets, leading to increased aggregability and release of vasoactive compounds post-stress. This highlights the cardiovascular impact of psychological stress on platelet function.

Area of Science:

  • Cardiovascular Physiology
  • Hematology
  • Psychoneuroimmunology

Background:

  • Platelet activation is implicated in atherogenesis and cardiac events.
  • Both physical and mental stressors can induce platelet activation.
  • Understanding stress-induced platelet changes, especially post-stress, is crucial.

Purpose of the Study:

  • To investigate platelet activation during and after a mental stress test.
  • To examine the relationship between stress markers and platelet response.
  • To clarify the temporal dynamics of stress-induced platelet changes.

Main Methods:

  • Eight healthy volunteers underwent the Stroop Colour Word Conflict Test.
  • Measured platelet aggregability ex vivo and plasma levels of beta-thromboglobulin and serotonin.

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  • Monitored cardiovascular parameters (heart rate, cardiac output, blood pressure) and plasma cyclic AMP.

    • Main Results:

    • Mental stress induced significant cardiovascular and adrenergic responses (increased heart rate, cardiac output, blood pressure, cyclic AMP).
    • Platelet aggregability was unchanged during stress but decreased afterward.
    • Plasma beta-thromboglobulin and serotonin levels significantly increased in the hour following stress.

    Conclusions:

    • Platelets are activated by mental stress.
    • This activation involves a delayed release of vasoactive substances from platelets after the stressor has ceased.
    • Mental stress has a significant, albeit delayed, impact on platelet function and potential thrombotic risk.