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Synovial sarcoma of the abdominal wall
1Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
Cancer
|July 15, 1993
Summary
Synovial sarcoma of the abdominal wall (SSAW) is rare, but its prognosis is similar to other locations. Poorly differentiated tumors, high mitotic rates, and larger size (> or = 5 cm) indicate a worse outcome.
Area of Science:
- Oncology
- Surgical Pathology
- Soft Tissue Tumors
Background:
- Synovial sarcoma is a rare soft tissue malignancy.
- Abdominal wall primary sites are exceptionally uncommon.
- Limited data exists on clinical and prognostic features for abdominal wall synovial sarcoma.
Purpose of the Study:
- To delineate clinical and prognostic features of synovial sarcoma of the abdominal wall (SSAW).
- To analyze the characteristics and outcomes of SSAW patients.
Main Methods:
- Retrospective analysis of 27 SSAW cases from the Soft Tissue Registry of the Armed Forces Institute of Pathology.
- Immunohistochemical stains performed on 18 cases.
- Review of patient demographics, tumor characteristics, and follow-up data.
Main Results:
- Median patient age was 23 years (range 8-58); 12 males and 15 females.
- Tumor types included biphasic (14), monophasic fibrous (8), and poorly differentiated (5).
- Tumor size (>= 5 cm), high mitotic rate, and poorly differentiated subtype correlated with increased mortality.
Conclusions:
- Survival rates for SSAW are comparable to synovial sarcoma in general.
- Poorly differentiated subtype, high mitotic rate, and tumor size >= 5 cm are associated with unfavorable prognosis.
- Pluripotential or arthrogenous mesenchyme may play a role in SSAW pathogenesis.