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Antigenic relatedness between ovine progressive pneumonia virus (OPPV) and HIV-1
1Respiratory Disease Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA 50010.
Abstract:
The antigenic relatedness between ovine progressive pneumonia virus (OPPV), a lentivirus that infects sheep, and human immunodeficiency virus (HIV-1) was examined by immunoblot analysis. Fourteen of 20 sheep sera, that were positive for OPPV antibodies on an immunodiffusion test, reacted with HIV-1 p24 on a commercial blot of HIV-1 and cell lysate proteins (Virostat, Portland, Maine). Sheep OPPV antisera did not bind to cellular antigens on a negative control blot of cellular proteins. There was no correlation between the ability to bind to HIV-1 p24 and the status of disease in the sheep. Twenty human anti-HIV-1 sera and two human HIV-1 negative sera were tested on OPPV and cell lysate (OPPV-CON) and cell lysate (CON) protein blots. None of the human serum samples tested reacted to OPPV specific proteins.
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