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Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency
E Mayatepek1, G F Hoffmann, H J Bremer
1University Children's Hospital, Heidelberg, Germany.
The Journal of Pediatrics
|July 1, 1993
Abstract:
In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease.