Related Experiment Videos
Expression of alpha isoforms of the Na,K-ATPase in human heart
R Zahler1, M Gilmore-Hebert, J C Baldwin
1Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Biochimica Et Biophysica Acta
|July 4, 1993
Abstract:
We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5%, alpha 1, 15% alpha 2 and 22.5% alpha 3 on average. There was an increase in expression of the alpha 3 isoform in samples from failing hearts, but expression of all three isoforms decreased in pressure-overloaded right ventricle (RV).