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Cardiac electrophysiological effects of U-50,488H on guinea-pig papillary muscle
S Alarcón1, J Hernández, M L Laorden
1Department of Physiology and Pharmacology, School of Medicine, Murcia, Spain.
Abstract:
Intracellular microelectrodes were used to study the electrophysiological effects of U-50,488H on guinea-pig papillary muscle. U-50,488H (10(-5) M) caused a significant decrease in the maximum rate of depolarization and a decrease in the action potential duration. At high concentration (5 x 10(-5) M) U-50,488H induced a significant decrease of resting potential, maximum rate of depolarization, action potential amplitude and the action potential duration. The administration of MR-2266 (5 x 10(-7) M) partially antagonized the cardiac electrophysiological effects of U-50,488H. These results suggest that the electrophysiological effects of U-50,488H may be partially due to an interaction with opioid receptors.