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The expression of aphidicolin-induced fragile sites in familial breast cancer patients
E L Mitchell1, B Woodhouse, J M Birch
1CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom.
Cancer Genetics and Cytogenetics
|June 1, 1993
Abstract:
The expression frequency of aphidicolin-induced fragile sites was examined in familial breast cancer patients to determine whether this parameter could be used as a marker of genetic susceptibility in at-risk individuals. No difference was found in expression frequency between the breast cancer patients and a group of normal individuals (p = 0.61). This indicates that the expression frequency of aphidicolin-induced fragile sites is not a suitable marker for assessing genetic susceptibility in familial breast cancer.