Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axonal degeneration in demyelinating disorders

R E Madrid, H M Wiśniewski

    Journal of Neurocytology
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Immune responses targeting peripheral nerves can cause both axonal degeneration and demyelination. This study suggests that nerve damage may occur as a "bystander" effect from nearby immune reactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vascular Parameters for Ambulatory Monitoring of Congestive Heart Failure Patients: Proof of Concept.

    Cardiovascular engineering and technology·2019
    Same author

    Retinal degeneration in primates raised on a synthetic human infant formula.

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
    Same author

    Microanalysis of Alzheimer disease NFT and plaques.

    Environmental geochemistry and health·2013
    Same author

    Aluminum neurotoxicity in mammals.

    Environmental geochemistry and health·2013
    Same author

    Electrical characterization of conductive textile materials and its evaluation as electrodes for venous occlusion plethysmography.

    Journal of medical engineering & technology·2013
    Same author

    Careers in biomedical engineering.

    IEEE pulse·2010
    Same journal

    GABA-immunoreactive neurons and terminals in the cat periaqueductal gray matter: a light and electron microscopic study.

    Journal of neurocytology·2006
    Same journal

    Increase of NG2-positive cells associated with radial glia following traumatic spinal cord injury in adult rats.

    Journal of neurocytology·2006
    Same journal

    Distribution of calcium-independent phospholipase A2 (iPLA 2) in monkey brain.

    Journal of neurocytology·2006
    Same journal

    Immunogold study of effects of prenatal exposure to lipopolysaccharide and/or valproic acid on the rat blood-brain barrier vessels.

    Journal of neurocytology·2006
    Same journal

    Reduction in parvalbumin expression in the zona incerta after 6OHDA lesion in rats.

    Journal of neurocytology·2006
    Same journal

    Potassium currents in primary cultured astrocytes from the rat corpus callosum.

    Journal of neurocytology·2006
    See all related articles

    Area of Science:

    • Neuroimmunology
    • Pathology
    • Peripheral Nerve Disorders

    Background:

    • Investigating immune-mediated peripheral neuropathies is crucial for understanding nerve damage.
    • Previous studies have explored immune responses to peripheral nerve components.

    Purpose of the Study:

    • To compare pathological changes in guinea pigs immunized with whole sciatic nerve versus purified peripheral nerve myelin.
    • To elucidate the mechanisms of axonal damage in immune-mediated demyelinating disorders.

    Main Methods:

    • Guinea pigs were immunized with either whole rabbit sciatic nerve or purified peripheral nerve myelin in Freund's adjuvant.
    • Histopathological examination of the spinal cord (L7, S1 segments), dorsal root ganglia (DRG), spinal roots, and sciatic nerves.

    Related Experiment Videos

    Main Results:

    • Both immunization groups exhibited pathological changes in posterior roots, DRG, and root entry zones.
    • Axonal degeneration and segmental demyelination occurred independently in posterior roots, affecting distinct myelinated axon populations.
    • No interdependence was observed between axonal degeneration and demyelination.

    Conclusions:

    • Axonal damage in immune-mediated neuropathies can result from proximity to cell-mediated immune reactions, a 'bystander' effect.
    • This finding has implications for understanding the pathogenesis of various demyelinating disorders.