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[Continuous postmenopausal estrogen-progesterone therapy]

P Affinito1, G A Tommaselli, R Morgera

  • 1II Facoltà di Medicina e Chirurgia, Istituto di Ginecologia ed Ostetrica, Università degli Studi Federico II, Napoli.

Minerva Ginecologica
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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Continuous conjugated equine estrogens and medrogestone effectively alleviate menopausal symptoms and improve lipid profiles in postmenopausal women over one year. This hormone therapy shows promise as a safe alternative for managing menopausal symptoms.

Area of Science:

  • Endocrinology
  • Gynecology
  • Cardiovascular Health

Context:

  • Postmenopausal hormone therapy aims to manage symptoms and mitigate health risks.
  • Continuous combined hormone therapy is an alternative to sequential regimens.

Purpose:

  • To evaluate the efficacy and safety of continuous conjugated equine estrogens plus medrogestone in postmenopausal women.
  • To assess effects on menopausal symptoms, endometrial histology, uterine bleeding, lipid profiles, bone mineral density, body weight, and blood pressure.

Summary:

  • One year of continuous conjugated equine estrogens and medrogestone significantly improved menopausal symptoms and reduced LDL cholesterol and total cholesterol.
  • Endometrial biopsies showed atrophic endometrium in all participants by month six, with amenorrhea achieved by month eight.

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  • No significant changes were observed in bone mineral density, body weight, or blood pressure.

    • Impact:

    • This regimen offers a safe and effective option for postmenopausal hormone replacement therapy.
    • It provides a viable alternative for women who cannot tolerate withdrawal bleeding associated with sequential therapy.