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Related Experiment Videos

Elevated plasma homocysteine in alcoholics

B Hultberg1, M Berglund, A Andersson

  • 1Department of Clinical Chemistry, University Hospital, Lund, Sweden.

Alcoholism, Clinical and Experimental Research
|June 1, 1993
PubMed
Summary

Elevated plasma homocysteine levels were observed in alcoholics undergoing detoxification, normalizing within two weeks. Abstinent alcoholics showed normal homocysteine, suggesting alcohol

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Area of Science:

  • Biochemistry
  • Neurology
  • Clinical Medicine

Background:

  • Alcoholism is linked to an increased risk of vascular disease, including stroke.
  • Elevated homocysteine (hyperhomocysteinemia) is a known risk factor for premature vascular disease.

Purpose of the Study:

  • To investigate plasma homocysteine concentrations in alcohol-dependent individuals undergoing detoxification.
  • To explore the relationship between alcohol consumption, plasma homocysteine, and stroke risk.

Main Methods:

  • Measured plasma homocysteine levels in hospitalized alcoholics (n=42) and controls.
  • Monitored homocysteine levels during detoxification.
  • Compared homocysteine levels in abstinent alcoholics (n=16) to controls.

Main Results:

  • Alcoholics undergoing detoxification exhibited significantly higher plasma homocysteine than controls.
  • Homocysteine levels normalized within 1-2 weeks of hospital admission.
  • Abstinent alcoholics showed no significant difference in plasma homocysteine compared to controls.

Conclusions:

  • Alcohol consumption, particularly during detoxification, leads to elevated plasma homocysteine.
  • The normalization of homocysteine upon abstinence suggests a reversible effect of alcohol.
  • Increased plasma homocysteine in alcoholics may contribute to their heightened risk of stroke.

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