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[Secondary Raynaud's phenomenon]

E Röther1, J Galle, H H Peter

  • 1Abteilung für Rheumatologie, Medizinische Universitätsklinik Freiburg.

Immunitat Und Infektion
|June 1, 1993
PubMed
Summary
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Raynaud's phenomenon (RP) involves episodic digital ischemia. Secondary RP, linked to connective tissue diseases, may involve endothelial injury, with ongoing research into its pathogenesis.

Area of Science:

  • Rheumatology and Immunology
  • Vascular Biology
  • Pathophysiology

Context:

  • Raynaud's phenomenon (RP) presents as episodic digital ischemia triggered by stressors.
  • Primary RP stems from peripheral vasomotor tone imbalance.
  • Secondary RP is associated with underlying disorders, notably collagen-vascular diseases like SLE and scleroderma.

Purpose:

  • To review the epidemiology and diagnosis of secondary RP in connective tissue diseases.
  • To discuss novel pathogenic concepts regarding secondary RP.
  • To integrate current understanding of endothelial function into RP pathogenesis.

Summary:

  • Secondary Raynaud's phenomenon is frequently associated with connective tissue diseases.
  • Endothelial injury, potentially mediated by autoantibodies and immune complexes, is implicated in secondary RP pathogenesis.

Related Experiment Videos

  • This review explores epidemiological data, diagnostic approaches, and emerging pathogenic theories for secondary RP.

    • Impact:

    • Enhances understanding of vascular involvement in connective tissue diseases.
    • Provides insights into the pathophysiology of secondary Raynaud's phenomenon.
    • Highlights the role of endothelial dysfunction in autoimmune-related vascular complications.