Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A perspective into ligand-receptor affinities using complex numbers

I M Klotz1

  • 1Department of Chemistry, Northwestern University, Evanston, IL 60208-3113.

Proceedings of the National Academy of Sciences of the United States of America
|August 1, 1993
PubMed
Summary

This study presents a new algebraic equation for ligand-receptor binding, allowing for complex equilibrium constants. This "ghost" equilibrium constant offers a novel perspective on binding thermodynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nature of protein complexes.

The Scientific monthly·2014
Same author

[46] Acylation with dicarboxylic acid anhydrides.

Methods in enzymology·2012
Same author

[47] Hybridization of chemically modified proteins.

Methods in enzymology·2012
Same author

The binding of organic ions by proteins.

Journal of the American Chemical Society·2010
Same author

Interactions between proteins and azosulfonamides.

Science (New York, N.Y.)·2010
Same author

The adsorption wave.

Chemical reviews·2010

Area of Science:

  • Biochemistry
  • Chemical Thermodynamics
  • Molecular Biophysics

Background:

  • Ligand-receptor interactions are fundamental in biological systems.
  • Traditional thermodynamic models use real-valued equilibrium constants.
  • Existing models may not capture all binding complexities.

Purpose of the Study:

  • To introduce an alternative algebraic binding equation.
  • To explore the implications of complex-valued equilibrium constants.
  • To evaluate numerical values of these novel constants.

Main Methods:

  • Derivation of a new binding equation using an algebraic approach.
  • Thermodynamic stoichiometric analysis.
  • Numerical evaluation of complex equilibrium constants for various complexes.

Related Experiment Videos

Main Results:

  • An alternative binding equation allowing complex equilibrium constants was derived.
  • The concept of "ghost" equilibrium constants was introduced.
  • Numerical values for ghost equilibrium constants were calculated for several ligand-receptor systems.

Conclusions:

  • Complex equilibrium constants offer a new mathematical framework for binding.
  • The ghost equilibrium constants provide insights into binding phenomena.
  • This algebraic approach complements traditional thermodynamic models.