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Related Experiment Videos

[Neurogenic senile vertebral spondylopathy]

A Meneghello1

  • 1Servizio di Radiologia, Ospedale Geriatrico, Padova.

La Radiologia Medica
|July 1, 1993
PubMed
Summary

Peripheral neuropathy in elderly patients can lead to neurogenic spinal arthropathy, causing bone destruction. This study identifies neuropathy in various conditions, including multiple myeloma and lymphoma, highlighting its diverse causes.

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Area of Science:

  • Neurology
  • Rheumatology
  • Geriatrics

Background:

  • Neurogenic spinal arthropathy is common in the elderly, often stemming from peripheral neuropathy.
  • Impaired sensation due to neuropathy prevents pain perception, leading to repeated joint trauma and bone destruction.
  • Historically linked to tabetic neuropathy, it's also seen in diabetes, syringomyelia, and trauma.

Purpose of the Study:

  • To investigate the incidence and causes of neurogenic spinal arthropathy in an elderly patient cohort.
  • To identify underlying conditions associated with peripheral neuropathy leading to spinal arthropathy.
  • To report novel associations of neurogenic spinal arthropathy with specific hematologic malignancies and treatments.

Main Methods:

  • Radiological review of lumbar spines in 4,922 patients (1989-1991).
  • Identification of 23 patients with findings suggestive of neurogenic spinal arthropathy.
  • Clinical, laboratory, and electromyographic confirmation of peripheral neuropathy.

Main Results:

  • Neurogenic spinal arthropathy was identified in 23 patients.
  • Peripheral neuropathy was confirmed in all cases.
  • Associated conditions included diabetes (7 cases), multiple myeloma (4 cases), Waldenström's macroglobulinemia (1 case), vincristine-treated lymphoma (2 cases), alcohol abuse (1 case), and analgesic abuse (2 cases).

Conclusions:

  • Peripheral neuropathy is a key factor in elderly neurogenic spinal arthropathy.
  • The condition is associated with a broader range of underlying pathologies than previously recognized, including hematologic disorders.
  • Further research is needed to elucidate the pathogenesis of neuropathy in these diverse elderly patient groups.

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