Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recombination and mammalian genome evolution

A Eyre-Walker1

  • 1Institute of Cell Animal and Population Biology, University of Edinburgh, U.K.

Proceedings. Biological Sciences
|June 22, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA.

Heredity·2016
Same author

Questioning evidence for recombination in human mitochondrial DNA.

Science (New York, N.Y.)·2007
Same author

Variation in synonymous codon use and DNA polymorphism within the Drosophila genome.

Journal of evolutionary biology·2006
Same author

Evolutionary genetics: direct evidence of recombination in human mitochondrial DNA.

Heredity·2004
Same author

A reanalysis of the indirect evidence for recombination in human mitochondrial DNA.

Heredity·2004
Same author

Does human mtDNA recombine?

Journal of molecular evolution·2001
Same journal

Chronic limb loading results in remarkable load carriage economy in growing fowl.

Proceedings. Biological sciences·2026
Same journal

Motion-from-structure in face perception: expectations of natural face motion depend on face shape.

Proceedings. Biological sciences·2026
Same journal

Unification and generalization of models of zygote survival.

Proceedings. Biological sciences·2026
Same journal

Phenological type- and diameter-dependent effects of individual light availability and interannual climate variation on tree growth.

Proceedings. Biological sciences·2026
Same journal

Interaction range of common goods shapes Black Queen dynamics beyond the cheater-cooperator narrative.

Proceedings. Biological sciences·2026
Same journal

Stingray spine diversity reflects performance trade-offs linked to puncture and breakability.

Proceedings. Biological sciences·2026
See all related articles

Mammalian DNA sequence guanine-cytosine (G+C) content correlates with recombination frequency. This relationship explains gene density variations and the distribution of repetitive elements like LINEs across the genome.

Area of Science:

  • Genomics
  • Molecular Biology
  • Mammalian Genetics

Background:

  • The distribution of guanine-cytosine (G+C) content and recombination rates within mammalian genomes is a key area of genetic research.
  • Previous studies have noted variations in G+C content and recombination across different genomic regions, but a direct relationship was not fully established.

Purpose of the Study:

  • To investigate the correlation between DNA sequence G+C content and recombination frequency in mammals.
  • To explore the implications of this relationship for genome organization, including gene density and repetitive element distribution.

Main Methods:

  • Comparative analysis of chromosome G+C content and chiasmata density across mammalian species (e.g., humans and mice).
  • Examination of G+C content in specific genomic regions, including the Y chromosome and loci with altered recombination rates.

Related Experiment Videos

Main Results:

  • A positive correlation was observed between chromosome G+C content and chiasmata density.
  • The non-pairing region of the Y chromosome exhibits low G+C content, consistent with reduced recombination.
  • Decreased recombination rates at specific loci were associated with lower G+C content, and lower variance in chiasmata density in mice correlated with lower variance in G+C content compared to humans.

Conclusions:

  • A significant relationship exists between mammalian DNA sequence G+C content and recombination frequency.
  • This correlation provides a framework for understanding higher gene density in G+C-rich isochores and the localization of long interspersed elements (LINEs) in G+C-poor regions.
  • The underlying cause of this relationship remains to be elucidated, with gene conversion being a potential factor.