[Intragenic variable number tandom repeats in coagulation factor VIII gene of Chinese origin]
1Thrombosis and Haemostasis Research Unit, Jiangsu Institute of Hematology, Suzhou Medical College.
Abstract:
Using polymerase chain reaction, we analysed the variable number tandom repeats (VNTR) in intron 13 of coagulation factor VIII gene in the Chinese. Study of 115 X chromosomes from 77 normal Chinese revealed that the VNTR is composed of at least 4 different alleles in the Chinese, i.e. 19, 20, 21, and 23 repeats 53% of the females analysed were heterozygous of this VNTR. The discovery and application of this new molecular genetic marker is of significance in genetic consultation and prenatal diagnosis of hemophilia A.
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