Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Viruses and Hodgkin's disease

R F Jarrett1

  • 1Department of Veterinary Pathology, University of Glasgow.

Leukemia
|August 1, 1993
PubMed
Summary

Epstein-Barr virus (EBV) is linked to many Hodgkin's disease (HD) cases, particularly in children and older adults. However, EBV is less involved in young adult HD, suggesting other infectious agents may cause this form of the disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The prevalence and characterisation of TRAF3 and POT1 mutations in canine B-cell lymphoma.

Veterinary journal (London, England : 1997)·2020
Same author

Human leukocyte antigens and genetic susceptibility to lymphoma.

Tissue antigens·2015
Same author

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.

Nature communications·2014
Same author

Idiopathic pulmonary hypertension.

Proceedings of the Royal Society of Medicine·2009
Same author

Measles virus and classical Hodgkin lymphoma: no evidence for a direct association.

International journal of cancer·2007
Same author

Molecular methods for virus discovery.

Developments in biologicals·2006

Area of Science:

  • Oncology
  • Virology
  • Epidemiology

Background:

  • Hodgkin's disease (HD) presents diverse histological and epidemiological profiles.
  • Epstein-Barr virus (EBV) is increasingly recognized as a factor in a substantial subset of HD cases.
  • EBV DNA and its latent protein LMP-1 are found in Reed-Sternberg cells in EBV-associated HD.

Purpose of the Study:

  • To investigate the association between Epstein-Barr virus (EBV) and Hodgkin's disease (HD) across different age groups.
  • To explore the etiological factors contributing to the distinct epidemiological patterns observed in HD.
  • To evaluate the role of EBV as a potential infectious agent in HD pathogenesis.

Main Methods:

  • Detection of clonal EBV genomes in affected tissues.
  • Localization of EBV within Reed-Sternberg (RS) cells.
  • Analysis of the age distribution of EBV-associated HD cases.

Main Results:

  • EBV genomes and the latent gene product LMP-1 are frequently detected in RS cells of EBV-associated HD.
  • EBV association is non-random, with higher prevalence in pediatric (<10 years) and older adult cases.
  • Young adult HD cases, especially nodular sclerosis subtype, show infrequent EBV positivity.

Conclusions:

  • Hodgkin's disease likely has multiple etiologies, with EBV implicated in specific subgroups.
  • Epidemiological data suggest an infectious etiology for HD, particularly in young adults.
  • The low EBV association in young adult HD suggests another infectious agent may be responsible for the incidence peak in this demographic.

Related Experiment Videos